Biochem/physiol Actions
Primary TargetNa+ channel
General description
A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+ - Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells.
A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+-Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331.Plattner, H., et al. 1994. J. Membr. Biol. 142, 229.Rando, T.A., et al. 1989. J. Gen. Physiol.93, 43.Rando, T.A., et al. 1986. Mol. Pharmacol.29, 467.
Packaging
5 mg in Alu drum
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Highly Toxic (H)
This product has met the following criteria: