VEGFR Tyrosine Kinase Inhibitor II

Code: 676481-5MG D2-231

Biochem/physiol Actions

Target IC50: 20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively

Reversible: yes

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€300.30 EACH
€369.37 inc. VAT

Biochem/physiol Actions

Target IC50: 20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively

Reversible: yes

Product competes with ATP.

Primary TargetKinase activities of KDR, Flt-1 and c-Kit

Cell permeable: yes

General description

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7.0 µM and 7.3 µM). Also displays antiangiogenic and antitumor properties. Does not inhibit the activities of CDK-1, c-Met, IGF-1R or PKA (IC50 >10 µM).

A pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 >10 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Furet, P., et al. 2003. Bioorg. Med. Chem. Lett.13, 2967.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
colorwhite
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inwet ice
solubilitymethanol: soluble, DMSO: 5 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.−20°C
Cas Number269390-69-4
This product has met the following criteria to qualify for the following awards:



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