General description
A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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