TGF-# RI KINASE INHIBITOR II 1PC X 2MG

Biochem/physiol Actions

Primary TargetActivin receptor-like kinase 4, 5, 7

Reversible: yes

Product competes with ATP.

Target IC₅₀: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively

Cell permeable: yes

General description

A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC₅₀ = 129 nM), 5 ( IC₅₀ = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC₅₀ = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816.DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.

Packaging

2 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)