Paclitaxel; Taxus sp.

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetPromotes assembly of microtubules and inhibits tubulins disassembly

General description

Antitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Legal Information

Taxol is a registered trademark of Bristol-Myers Squibb Co.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Derry, W.B., et al. 1995. Biochemistry 34, 2203.Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.Hornback, N.B., et al. 1994. In Vivo8, 819.Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.Ding, A.H., et al. 1990. Science248, 370.Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

Packaging

5 mg in Glass bottle

25, 100 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)