Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary Targetγ-secretase
Cell permeable: yes
General description
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.
Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer's disease.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Packaging
1 mg in Plastic ampoule
Packaged under inert gas
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sequence
Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: