Biochem/physiol Actions

Reversible: yes

Primary Targetβ-secretase

Product does not compete with ATP.

Cell permeable: yes

Target IC₅₀: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

General description

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.

A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

Packaging

1, 5 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Sequence

Z-Val-Leu-Leu-CHO

Warning

Toxicity: Standard Handling (A)