Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetp38 MAP kinase

Cell permeable: yes

Target IC₅₀: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen

General description

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

1, 10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)