Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetInhibits glutamate release and blocks Na+ channels

Cell permeable: yes

General description

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na⁺ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).

A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na⁺ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington's disease).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.Schiefer, J., et al. 2002. Mov. Disord.17, 748.Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.Mizoule, J., et al. 1985. Neuropharmacology24, 767.

Packaging

Packaged under inert gas

50 mg in Alu drum

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic (F)