InSolution Rac1 Inhibitor II; Z62954982

Code: 553512-10MG D2-231

General description

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) i...


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€190.50 10MG
€234.32 inc. VAT

General description

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ferri, N., et al. 2009. J. Med. Chem.52, 4087.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Physical form

A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Irritant (B)

assay≥93% (HPLC)
formliquid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
SMILES stringCC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O
storage conditiondesiccated (hygroscopic), avoid repeated freeze/thaw cycles, protect from light, OK to freeze
storage temp.−20°C
Cas Number1090893-12-1
This product has met the following criteria to qualify for the following awards:



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