Biochem/physiol Actions

Reversible: no

Target IC₅₀: 50, 100, 430, and ﹤25 nM for caspase-1,-8, -9, and -3, respectively

Product does not compete with ATP.

Primary Targetcaspase-1

Cell permeable: yes

General description

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50, 100, 430, and ﹤25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.Caserta, T.M., et al. 2003. Apoptosis8, 345.Rebbaa, A., et al. 2003. Oncogene22, 2805.

Packaging

1 mg in Plastic ampoule

5 mg in Glass bottle

Packaged under inert gas

Physical form

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Sequence

Q-Val-Asp-CH₂-OPh

Warning

Toxicity: Irritant (B)