Biochem/physiol Actions
Cell permeable: no
Reversible: yes
Product does not compete with ATP.
Primary TargetPKCε Translocation
General description
An octapeptide that selectively inhibits the translocation of PKCε to subcellular sites. Inhibition of PKCε translocation is known to specifically block phorbol ester or norepinephrine-mediated regulation of contraction in cardiomyocytes.
An octapeptide that selectively inhibits the translocation of protein kinase Cε to subcellular sites in a reversible manner. Inhibition of PKCε translocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Sold under license of U.S. Patent 5,783,405.
Other Notes
Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.
Packaging
5 mg in Plastic ampoule
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.
Sequence
H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: