Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetA natural ligand for PPARγ-dependent adipogenesis

General description

A metabolite of PGD₂ that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Petrova, T.V., et al. 1999. Proc. Natl. Acad. Sci. USA96, 4668.Ricote, M., et al. 1998. Nature 391, 79.Forman, B.M., et al. 1995. Cell 83, 803.Kliewer, S.A., et al. 1995. Cell83, 813.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)