General description

A cell-permeable, PLD1/2 inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Su, W., et al. 2009. Mol Pharmacol75, 437.Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)