Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetCOX-1 and COX-2 activities
Cell permeable: yes
Target IC50: 19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
General description
A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC50 = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC50 = 70 µM), prevents DMBA-induced preneoplastic lesions (ED50 = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.
A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Roberti, M., et al. 2003. J. Med. Chem.46, 3546.Rimando, A.M., et al. 2002. J. Agric. Food Chem.50, 3453.Manickam, M., et al. 1997. J. Nat. Prod.60, 609.
Packaging
Packaged under inert gas
10 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Carcinogenic / Teratogenic (D)
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