Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages

Cell permeable: yes

General description

A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.Bork, P.M., et al. 1997. FEBS Lett. 402, 85.Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.

Packaging

50 mg in Plastic ampoule

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)