Biochem/physiol Actions
Cell permeable: no
Reversible: no
Primary TargetInhibitor of bone resorption
Product does not compete with ATP.
General description
A calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget′s disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget's disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Fromigue, O., et al. 2000. J. Bone Miner. Res.15, 2211.Fitton, A., and McTravish, D. 1991. Drugs41, 289.
Packaging
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
This product has met the following criteria to qualify for the following awards: