p38 MAP Kinase Inhibitor VIII

General description

A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β₂ (82% and 93% inhibition with 1 µM inhibitor, respectively; IC₅₀ of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC′s in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ottosen, E.R., et al. 2003. J. Med. Chem.46, 5651.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)