PRMT Inhibitor VII; DB867

Biochem/physiol Actions

Reversible: yes

Primary TargetPRMT1

General description

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC₅₀ = 110 µM) and PRMT6 (IC₅₀ = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.Please note that the molecular weight for this compound is batch-specific due to variable water content.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Xu, J., et al, 2013. Mol. Cell.51, 1.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)