Biochem/physiol Actions

Primary TargetGABA_A

General description

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (K_b = 190 µM).

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (K_b = 190 mM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Muroi, Y., et al. 2009. Biophys. J.96, 499.Beato, M., et al. 2007. J. Physiol.580, 171.Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)