Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetL-type Ca2+ channels

General description

Relatively selective blocker of L-type Ca²⁺ channels. One of the most extensively studied Ca²⁺ channel blockers of 1,4-dihydropyridine-type and a pharmacologically useful vasodilator. Induces apoptosis in human glioblastoma cells.

Relatively selective blocker of L-type Ca²⁺ channels. One of the most extensively studied blockers of 1,4-dihydropyridine-type Ca²⁺ channels, and a pharmacologically-useful vasodilator. Induces apoptosis in human glioblastoma cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Reid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.Kondo, S., et al. 1995. J. Neurosurg.82, 469.Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.Akman, M.S., et al. 1993. Endocrinology132, 1286.Cirillo, M., et al. 1993. Circ. Res.72, 847.Young, R.J., et al. 1993. Biochim. Biophys. Acta1146, 81.Janis, R., et al. 1987. Adv. Drug Res.16, 311.

Packaging

250 mg in Plastic ampoule

Reconstitution

Following reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)