Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targetc-Myc

Cell permeable: yes

General description

A cell-permeable, thiazolidinone compound that specifically inhibits c-Myc-Max interaction, thereby preventing the transactivation of c-Myc targeted gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (Effective concentration: 64 µM using c-Myc-transfected Rat1a fibroblasts).

A cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction, thereby preventing the transactivation of c-Myc target gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 µM using c-Myc transfected Rat1a fibroblasts).

Legal Information

Sold under license of U.S. Patent 7,026,343.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yin, X., et al. 2003. Oncogene22, 6151.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)