MK2a Inhibitor

Code: 475863-5MG D2-231

Biochem/physiol Actions

Cell permeable: no

Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)

Reversible: yes

Produc...


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€270.19 EACH
€332.33 inc. VAT

Biochem/physiol Actions

Cell permeable: no

Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)

Reversible: yes

Product does not compete with ATP.

Primary TargetMk2α

General description

A reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.

A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Davidson, W., et al. 2004. Biochemistry43, 11658.Lukas, S.M., et al. 2004. Biochemistry43, 9950.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
colorpale yellow
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityethanol: 5 mg/mL, DMSO: 5 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number41179-33-3
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