Biochem/physiol Actions
Cell permeable: no
Reversible: yes
Product does not compete with ATP.
Target Ki: 21 nM and 35 nM for 20S and 26S proteasome, respectively
Primary Target20S proteasome
General description
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
Packaging
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sequence
Z-Leu-Leu-Nva-CHO
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: