Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetInhibits cell proliferation and angiogenesis

Product does not compete with ATP.

General description

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Aizu-Yokata, E., et al. 1995. Cancer Res.55, 1863.Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.D'Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.Forsis, T., et al. 1994. Nature368, 237.

Packaging

10, 50 mg in Alu drum

Warning

Toxicity: Toxic (F)