Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary Targetbroad range protease

General description

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α₂M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.Boisset, N., et al. 1992. J. Struct. Biol.108, 221.Barrett, A.J. 1980. Methods Enzymol.80, 737.

Packaging

1, 10 mg in Plastic ampoule

Physical form

Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.

Warning

Toxicity: Standard Handling (A)