GUANOSINE 3;5-CYCLIC MONOP 1PC X 1UMOL

Biochem/physiol Actions

Target K_i: 30 nM against PKG1α & 1β

Reversible: no

Primary TargetPKG1α & 1β

Product does not compete with ATP.

Cell permeable: yes

General description

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (K_i = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM). Also reported to block the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.

A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (K_i = 30 nM). Blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM) and the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wei, J.Y., et al. 1996. Biochemistry35, 16815.Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

Packaging

1 µmol in Plastic ampoule

Warning

Toxicity: Standard Handling (A)