Guanosine 3#,5#-cyclic Monop 1PC X 1UMOL

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetPKG1α

Cell permeable: yes

General description

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.

A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.

Other Notes

Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498.Lee, S.J., et al. 1996. Dev. Biol.180, 324.Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.Willmott, N., et al. 1996. J. Biol. Chem.271, 3699.Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

Packaging

1 µmol in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)