Biochem/physiol Actions

Reversible: no

Target IC₅₀: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β

Product does not compete with ATP.

Primary TargetRelevant kinase inactive control

Cell permeable: yes

General description

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC₅₀ >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC₅₀ >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)