Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetL-type Ca2+ channel

Product does not compete with ATP.

General description

Synthetic (+)-cis isomer that acts as an L-type Ca²⁺ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

Packaging

100 mg in Plastic ampoule

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)