2#,5#-DIDEOXYADENOSINE 1PC X 1MG

Biochem/physiol Actions

Reversible: no

Target IC₅₀: 3 µM against adenylate cyclase

Product does not compete with ATP.

Cell permeable: yes

General description

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.

Membrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC₅₀ = 3 µM for detergent solubilized rat brain membranes; IC₅₀ = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC₅₀ = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ibrahimi, A., et al. 1999. Am. J. Physiol.276, C487.Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.Bushfield, M., et al. 1990. Mol. Pharmacol.38, 848.Reid, I.R., et al. 1990. Am. J. Physiol.258, E708.Legrand, A.B., et al. 1990. Biochem. Pharmacol.40, 1103.Johnson, R.A., et al. 1989. Mol. Pharmacol.35, 681.Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA77, 6800.

Packaging

1 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)