Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetCOX-2 from human monocytes

Cell permeable: yes

Target IC₅₀: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood

General description

A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC₅₀ = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).

A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC₅₀ = 650 nM) and in whole blood (IC₅₀ = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC₅₀ >10 µM) and in whole blood (IC₅₀ >100 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Palomer, A., et al. 2002. J. Med. Chem.45, 1402.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)