Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetInhibitor of mitosis
General description
Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189.Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929.Santell, L. 1992. Exp. Cell Res. 201, 358.Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.
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Packaging
1 g in Alu drum
Warning
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
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