Biochem/physiol Actions

Cell permeable: no

Primary TargetMetal ion chelator

Reversible: no

Product does not compete with ATP.

General description

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid's ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.

A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid′s ability to clump together, apparently by trapping the Cu²⁺ and Zn²⁺ that reduces the build-up of these deposits. Exhibits greater affinity for Cu²⁺ and Zn²⁺ than for Ca²⁺ and Mg²⁺. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer′s disease.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Melov, S. 2002. Trends Neurosci.25, 121.Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408.Helmuth, L., et al. 2000. Science290, 1273.Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.

Packaging

Packaged under inert gas

1 g in Plastic Bag(s)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)