Cathepsin Inhibitor III

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetcathepsin B

Product does not compete with ATP.

k₂/K_i = 1 x 10⁴ M_-¹ sec_-¹

General description

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1 x 10⁴ M^-1 sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 6.6 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 1 x 10³ M^-1 sec^-1).

Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1.0 x 10⁴ M^-1sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1sec^-1), cathepsin S (k₂/Ki = 6.6 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 1.0 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Z-Phe-Gly-NHO-Bz-pOMe

Warning

Toxicity: Standard Handling (A)