Caspase-3/7 Inhibitor I

Code: 218826-1MG D2-231

Biochem/physiol Actions

Reversible: yes

Primary Targetcaspase-3

Product does not compete with ATP.

Target Ki: 60 nM, 170 nM, against caspase-3 an...


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Your Price
€232.92 1MG
€286.49 inc. VAT

Biochem/physiol Actions

Reversible: yes

Primary Targetcaspase-3

Product does not compete with ATP.

Target Ki: 60 nM, 170 nM, against caspase-3 and caspase-7, respectively

Cell permeable: yes

General description

A potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).

A potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Inhibits caspase-9 to a lesser extent (Ki(app) = 3.1 µM). Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. Reported to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lee, D., et al. 2001. J. Med. Chem.44, 2015.Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
coloryellow
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilitymethanol: 10 mg/mL, DMSO: 200 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.−20°C
Cas Number220509-74-0
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