Biochem/physiol Actions

Primary Targetcaspase-6

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable, irreversible inhibitor of caspase-6 (Mch-2).

A cell-permeable, irreversible inhibitor of caspase-6. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Packaging

1 mg in Plastic ampoule

250 µg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH₂F*

Warning

Toxicity: Standard Handling (A)