Caspase-3 Inhibitor III

Biochem/physiol Actions

Reversible: no

Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Cell permeable: yes

General description

A potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Packaging

1, 5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Sequence

Ac-Asp-Glu-Val-Asp-CMK

Warning

Toxicity: Standard Handling (A)