Biochem/physiol Actions
Cell permeable: no
Reversible: no
Primary Targetcathepsin B
Product does not compete with ATP.
Target IC50: 2.24 nM for rat liver cathepsin B
General description
An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).
A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Chan, V.J., et al. 1999. Biochem. J. 340, 113.Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.Yamamoto, A., et al. 1997. J. Biochem.121, 974.Inubushi, T., et al. 1994. J. Biochem. 116, 282.Murata, M., et al. 1991. FEBS Lett. 280, 307.Towatari, T., et al. 1991. FEBS Lett. 280, 311.
Packaging
1 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: