Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetcathepsin B

Product does not compete with ATP.

Target IC₅₀: 2.24 nM for rat liver cathepsin B

General description

An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC₅₀ = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC₅₀ = 2.24 nM for rat liver cathepsin B).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chan, V.J., et al. 1999. Biochem. J. 340, 113.Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.Yamamoto, A., et al. 1997. J. Biochem.121, 974.Inubushi, T., et al. 1994. J. Biochem. 116, 282.Murata, M., et al. 1991. FEBS Lett. 280, 307.Towatari, T., et al. 1991. FEBS Lett. 280, 311.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)