Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner

Primary TargetCa²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner

General description

An inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).

An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun.229, 154.Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol.74, 305.Zhu, Y., and Ikeda, S.R. 1993. Neurosci.Lett. 155, 24.

Packaging

500 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)