Biochem/physiol Actions
Primary Targetphosphotyrosine phosphatase
Cell permeable: no
Reversible: no
Target Ki: 100 nM for phosphotyrosine phosphatase
Product does not compete with ATP.
Target IC50: 18 nM against PTEN
General description
A potent inhibitor of phosphotyrosine phosphatase activity (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Reconstitution
Unstable in solution; reconstitute just prior to use.
Warning
Toxicity: Harmful (C)
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