Biochem/physiol Actions
Cell permeable: no
Reversible: yes
Product competes with ATP.
Primary TargetProtein kinase C
Target Ki: 10 nM against protein kinase C
General description
A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.Kuchera, S., et al. 1993. Agents Actions 39, C169.Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Packaging
1 mg in Plastic ampoule
250 µg in Plastic ampoule
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: