Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Cell permeable: yes
Target Ki: 1.3 µM in binding Bcl-2
General description
A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (﹤300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
A cell-permeable molecule that targets the BH3 domain interaction and selectively induces apoptosis in Bcl-2-overexpressing cells (﹤300 nM in MDA-MB435B breast cancer cells). Exhibits little effect on a variety of primary cells and Bcl-xL-dependent cells, even at a concentrations as high as 5 µM. Inhibits the binding of Bid BH3 to Bcl-2 thereby blocking the anti-apoptotic activity of Bcl-2.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Real, P.J., et al. 2004. Cancer Res. 64, 7947.
Packaging
5 mg in Glass bottle
Packaged under inert gas
Warning
Toxicity: Carcinogenic / Teratogenic (D)
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