Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Primary TargetPARP

General description

A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.

Packaging

100 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.

Warning

Toxicity: Irritant (B)