General description

Anti-CD34 recognizes a cell surface antigen of approximately 110 kD that is expressed selectively on human hematopoietic progenitor cells, including myeloid and lymphoid lineage progenitors. It is a marker of choice for identifying and counting the blasts in leukemia. In addition, this marker is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule in greater amounts than non-proliferating endothelial cells. Anti-CD34 labels greater than 85% of angiosarcoma and Kaposi’;s sarcoma, but shows low specificity.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

CD34 Positive Control Slides, Product No. 134S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality