General description

A highly selective agonist of adenosine A3 receptor (K_i = 330 pM)

An adenosine analog that acts as a highly selective agonist of adenosine A₃ receptor (K_i = 330 pM, 820 nM, 470 nM for A₃, A₁ and A_2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kim, H. O., et al. 1994. J Med Chem.37, 3614.Laudadio, M. A., et al. 2004. Epilepsy Res.59, 83.Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther.319, 1200.

Packaging

Packaged under inert gas

2 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)