Meridians Air-Dryable™ mixes are glycerol-free mixes, ideal for developing ambient temperature, air-dried, multiplex qPCR and RT-qPCR molecular diagnostic tests and are suited for high-throughput, automated platforms or microfluidic qPCR platforms. Can also be used wet.
Molecular diagnostic tests are progressively moving towards dried formats. There are several advantages for this, including ambient temperature shipping and storage, extended shelf-life, reduced operating steps and potential errors and increased flexibility in sample volume. In order to be compatible with air or oven drying, however, enzyme preparations must be glycerol-free and include specialised excipients that preserve the mixture as it is exposed to higher temperatures.
Air-Dryable™ qPCR Mix (4x) is used for the development of multiplex molecular diagnostic tests, enabling highly sensitive detection of target DNA, whereas the Air-Dryable ™ 1-Step RT-qPCR Mix (4x) can be used for the development of multiplex molecular diagnostic tests both RNA and DNA targets. The air drying does not affect the specificity or reproducibility of the assay but increases the flexibility of the volume of sample that can be added, increasing sensitivity and also makes them ideal for microfluidic qPCR and point of care platforms.
- Create ultra-sensitive multiplex qPCR tests for low-copy number targets
- Glycerol-free mixes are pre-formulated with a specialised blend of excipients, compatible with air-drying
- High-tolerance to PCR inhibitors carried over during purification, improving reproducibility
- Can be used wet or it can be dried, for developing an ambient-temperate stable assay
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