K-252a, from Nonomuraea longicatena, >=98% (HPLC)

Code: K1639-100UG D2-231

Application

K-252a has been used: as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in ratsas a Trk inhibitor for inducing in vitro

read more

Your Price
€263.00 100UG
€323.49 inc. VAT
REQUEST

Application

K-252a has been used: as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in ratsas a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly

Biochem/physiol Actions

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC50 values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.

antibiotic activity spectrumviruses
assay≥98% (HPLC)
biological sourceNonomuraea longicatena
formsolid
Gene Informationhuman ... NTRK1(4914)rat ... Prkca(24680)
InChI keyKOZFSFOOLUUIGY-SOLYNIJKSA-N
InChI1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
mode of actionenzyme | inhibits
Quality Level200
shipped indry ice
SMILES string[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
solubilityDMSO: 1 mg/mL, DMF: 1 mg/mL
storage temp.−20°C
Cas Number99533-80-9
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN

GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.