Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetNGF-induced neuronal differentiation

General description

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb⁺ >K⁺ >Cs⁺ >Ag⁺ >NH₄⁺ >Na⁺ >Li⁺). Induces K⁺ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K⁺ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K⁺ concentration. Useful in studies of K⁺ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K⁺ conductivity in cell membranes at concentrations as low as 10^-8 M. Often used in membrane electrode systems for determining K⁺ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Harada, H., et al. 1994. Biochim. Biophys. Acta1220, 310.Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.Orlov, V.N., et al. 1994. FEBS Lett.345, 104.Acra, S., et al. 1993. Am. J. Physiol.264, G45.Cornet, M., et al. 1993. J. Membr. Biol.131, 55.Deckers, C.L., et al. 1993. Exp. Cell Res.208, 362.Dimroth, P., and Thomer, A. 1993. Biochemistry32, 1734.Opanasenko, V.K., et al. 1992. FEBS Lett.307, 280.Pape, P.C., et al. 1992. J. Physiol.449, 219.Ahmed, S., and Booth, I.R. 1983. Biochem. J.212, 105.Lerner, A., et al. 1982. FEBS Lett.146, 9.

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Packaging

100 mg in Glass bottle

25 mg in Fibre carton

Warning

Toxicity: Highly Toxic (H)