TNF-# ANTAGONIST 1PC X 1MG

Code: 654255-1MG D2-231

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC50: 5 µM as TNF-α antagonist

Product does not compete with ATP.

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€455.50 EACH
€560.27 inc. VAT

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC50: 5 µM as TNF-α antagonist

Product does not compete with ATP.

General description

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

Legal Information

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Packaging

1 mg in Plastic ampoule

Sequence

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
formlyophilized
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubility5% acetic acid: 5 mg/mL, water: 1 mg/mL
storage conditiondesiccated (hygroscopic), OK to freeze
storage temp.−20°C
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